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Bookks authors relative mutation brca1 in breast cancer

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From: al3k5
Added: 31.12.2020
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Background: First-degree relatives of patients with breast or ovarian cancer have increased risks for these cancers. Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis. Ovarian cancer patients were tested for BRCA1 mutations. The breast cancer SIR was 1.
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Study Estimates Relative Risk of Breast and Ovarian Cancer for 25 Genetic Mutations

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Study Estimates Relative Risk of Breast and Ovarian Cancer for 25 Genetic Mutations

PALB2 has been recently identified as breast cancer susceptibility gene in western populations. Some genetic variants identified in the cases were then studied in normal controls with no personal or family history of breast cancer. All the truncating mutations occured in exon 4 of PALB2, and there were still three unclassified variants were detected in the same fragment. We found that exon 4 accounted for Our results suggested that a detection of exon 4 before the assay of the whole PALB2 gene might be a cost-effective approach to the screening of Chinese population. This is a preview of subscription content, access via your institution.
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Providing cutting-edge scholarly communications to worldwide, enabling them to utilize available resources effectively. We aim to bring about a change in modern scholarly communications through the effective use of editorial and publishing polices. E-mail : bhuvaneswari. Daniele M. Although breast cancer is a disease that affects mostly women, the lifetime risk in men is about 1 in
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Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Breast and ovarian cancer incidence rates for mutation carriers were estimated using a modified segregation analysis, based on the occurrence of these cancers in the relatives of mutation-carrying index case patients. We found some evidence for a reduction in risk in women from earlier birth cohorts and for variation in risk by mutation position for both genes.
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